http://www.noarthritis.com/nightshades.htm
They contain neurotoxins. Most people make an anti-toxin, but I do not. (So it’s not exactly an allergy, more of a deficiency).
“In some people, the nightshade vegetables appear to cause arthritic pain, arthritic deformity, nerve pain, and other central nervous system problems…
The alkaloids found in common nightshade vegetables are powerful, with effects on various tissues, including the membranes of the cells of the body. They bioaccumulate: they remain unprocessed by the body and accumulate in tissues.
In addition, nightshade alkaloids are cholinesterase inhibitors, just as organophosphate pesticides are. They affect the central nervous system and cause, among other adverse effects, pain.”
from http://www.getting-started-with-healthy-eating.com/nightshade-vegetables.html
I am told that the toxins shorten nerve endings, essentially deadening them. I stopped having heart palpitations and severe mood swings when I stopped having nightshades.