Fantastic article explaining some of the science:
http://www.westonaprice.org/food-features/nightshades
The poisonous compounds in and drugs from nightshades include lycopene, calcitriol, solanine, nicotine, atropine, scopolamine, hyoscyamine and capsaicin.
excerpts:
regarding potatoes
“Potatoes naturally produce solanine and chaconine, a related glycoalkaloid, as a defense mechanism against insects, disease and predators (humans included). Potato leaves, stems and shoots are naturally high in these glycoalkaloids. When potato tubers are exposed to light, they turn green and increase glycoalkaloid production. This is a natural defense to help prevent the uncovered tuber from being eaten.
In potato tubers, 30–80 percent of the solanine develops in and close to the skin. If the potato looks green under the skin, throw it away; likewise if it has begun to sprout, just discard it.”
regarding treatment:
“But the real question is, why are some people more sensitive than others? Nutrient deficiencies certainly come into play. For example, if you don’t have enough magnesium, you will be more prone to calcinosis. Deficiency in vitamin D may exacerbate the problem. The speed at which one’s liver and kidneys detoxify these compounds plays a huge role, and this is dependent both on genetics and nutrition.
A key nutrient is vitamin K2—Dr. Price’s famous Activator X. I love this study on vitamin K2: The Effect of Vitamin K2on Experimental Calcinosis. 18 They gave rats calcinosis by giving them way too much vitamin D2. D2 tends to cause calcinosis anyway. What did they find? A high dose of vitamin K2 suppressed experimental calcification of soft tissues induced by vitamin D2. So if you want to avoid problems with nightshades, be sure to eat goose liver, cheese, fatty grass-fed meats and pasture-fed butter—and take your butter oil.”
regarding gluten-free diets and nightshades:
“For those of you have gone off gluten and you’re wondering why you still have digestive problems, it may be because of tomatoes. Potatoes can be another culprit, as many gluten-free products are filled with potato starch.”